Halogenated Rocaglate Derivatives
Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses
- verfasst von
- Catherine Victoria, G枚ran Schulz, Mara Kl枚hn, Saskia Weber, Cora M. Holicki, Yannick Br眉ggemann, Miriam Becker, Gisa Gerold, Martin Eiden, Martin H. Groschup, Eike Steinmann, Andreas Kirschning
- Abstract
The synthesis of a library of halogenated rocaglate derivatives belonging to the flavagline class of natural products, of which silvestrol is the most prominent example, is reported. Their antiviral activity and cytotoxicity profile against a wide range of pathogenic viruses, including hepatitis E, Chikungunya, Rift Valley Fever virus and SARS-CoV-2, were determined. The incorporation of halogen substituents at positions 4鈥�, 6 and 8 was shown to have a significant effect on the antiviral activity of rocaglates, some of which even showed enhanced activity compared to CR-31-B and silvestrol.
- Organisationseinheit(en)
-
Institut f眉r Organische Chemie
- Externe Organisation(en)
-
Ruhr-鲍苍颈惫别谤蝉颈迟盲迟 Bochum
Stiftung Tier盲rztliche Hochschule Hannover
鲍苍颈惫别谤蝉颈迟盲迟 Ume氓
Friedrich-Loeffler-Institut (FLI)
- Typ
- Artikel
- Journal
- Journal of medicinal chemistry
- Band
- 67
- Seiten
- 289-321
- Anzahl der Seiten
- 33
- ISSN
- 0022-2623
- Publikationsdatum
- 11.01.2024
- Publikationsstatus
- 痴别谤枚蹿蹿别苍迟濒颈肠丑迟
- Peer-reviewed
- Ja
- ASJC Scopus Sachgebiete
- Molekularmedizin, Wirkstoffforschung
- Ziele f眉r nachhaltige Entwicklung
- SDG 3 鈥� Gute Gesundheit und Wohlergehen
- Elektronische Version(en)
-
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